208293 | Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - Calbiochem

208293
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₂₁NO₄S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208293-10MG
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          Glass bottle 10 mg
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          Description
          OverviewAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).
          Catalogue Number208293
          Brand Family Calbiochem®
          SynonymsTMEM16 Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I
          References
          ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
          Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₈H₂₁NO₄S
          Chemical formulaC₁₈H₂₁NO₄S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208293

          References

          Reference overview
          Fuente, R., et al. 2011, Mol Pharmacol. 73, 758.
          Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-May-2012 JSW
          SynonymsTMEM16 Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I
          DescriptionAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₂₁NO₄S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml; pale yellow solution)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
          Namkung, W., et al. 2011, J Biol Chem. 286, 2365.