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504523 | CP-101,606 - CAS 134234-12-1 - Calbiochem

504523
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₅NO₃ 134234-12-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04523.0001
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          Glass bottle 5 mg
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          Description
          OverviewA highly selective antagonist for NR2B subunit containing NMDA receptors (IC50 = 0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D). Widely used as neuroprotective, analgesic, antidepressant, and anti-Parkinsonian agent in research.
          Catalogue Number504523
          Brand Family Calbiochem®
          SynonymsTraxoprodil, CP-101606, (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol, NMDA Antagonist VI
          References
          ReferencesTaniguchi, K., et al. 2009. British J. Pharmacol. 122, 809.
          Menniti, F., et al. 1997. Eur. J. Pharmacol. 331, 117.
          Nicholson, K., et al. 2007. Behavioural Pharmacology 18, 731.
          Bullock, M., et al. 2006. Annals of the New York Academy of Sciences 890, 51.
          Preskorn, S., et al. 2008. J. Clin. Psychopharmacol. 28, 631.
          Yurkewicz, L., et al. 2005. J. Neurotrauma. 22, 1428.
          Product Information
          CAS number134234-12-1
          FormWhite powder
          Hill FormulaC₂₀H₂₅NO₃
          Chemical formulaC₂₀H₂₅NO₃
          Structure formula Image
          Applications
          Biological Information
          Primary TargetNMDA receptors
          Primary Target IC<sub>50</sub>0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Taniguchi, K., et al. 2009. British J. Pharmacol. 122, 809.
          Menniti, F., et al. 1997. Eur. J. Pharmacol. 331, 117.
          Nicholson, K., et al. 2007. Behavioural Pharmacology 18, 731.
          Bullock, M., et al. 2006. Annals of the New York Academy of Sciences 890, 51.
          Preskorn, S., et al. 2008. J. Clin. Psychopharmacol. 28, 631.
          Yurkewicz, L., et al. 2005. J. Neurotrauma. 22, 1428.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          SynonymsTraxoprodil, CP-101606, (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol, NMDA Antagonist VI
          DescriptionA highly selective antagonist for NR2B subunit containing NMDA receptors (IC50 = 0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D). Widely used as neuroprotective, analgesic, antidepressant, and anti-Parkinsonian agent in research.
          FormWhite powder
          CAS number134234-12-1
          Chemical formulaC₂₀H₂₅NO₃
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (35 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTaniguchi, K., et al. 2009. British J. Pharmacol. 122, 809.
          Menniti, F., et al. 1997. Eur. J. Pharmacol. 331, 117.
          Nicholson, K., et al. 2007. Behavioural Pharmacology 18, 731.
          Bullock, M., et al. 2006. Annals of the New York Academy of Sciences 890, 51.
          Preskorn, S., et al. 2008. J. Clin. Psychopharmacol. 28, 631.
          Yurkewicz, L., et al. 2005. J. Neurotrauma. 22, 1428.