236013 | COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem

236013
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₁Cl₂N₃OS 1177728-24-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      236013-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
          Catalogue Number236013
          Brand Family Calbiochem®
          SynonymsN-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472
          References
          ReferencesMichaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.
          Product Information
          CAS number1177728-24-3
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₀H₂₁Cl₂N₃OS
          Chemical formulaC₂₀H₂₁Cl₂N₃OS
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCOX-2
          Primary Target IC<sub>50</sub>at 10.0 µM, % inhibition of COX-1 and COX-2 = 5.1 and 26.36
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          236013

          References

          Reference overview
          Michaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2011 RFH
          SynonymsN-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472
          DescriptionA thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1177728-24-3
          Chemical formulaC₂₀H₂₁Cl₂N₃OS
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml) or Ethanol (0.5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesMichaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.