534363 CNTF Mimetic, P6 Peptide - Calbiochem

534363
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₅₅H₉₀N₁₄O₁₆

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34363.0001
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          Glass bottle 10 mg
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          Description
          OverviewA brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number534363
          Brand Family Calbiochem®
          SynonymsCiliary Neurotrophic Factor Epitope Peptide 6
          DescriptionCNTF Mimetic, P6 Peptide
          References
          ReferencesKazim, S., et al. 2015. Plos One. 10, e0118627.
          Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
          Li, B., et al. 2010. FEBS Lett. 584,3359.
          Product Information
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₅₅H₉₀N₁₄O₁₆
          ReversibleY
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-VGDGGLFEKKL-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          CNTF Mimetic, P6 Peptide - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Kazim, S., et al. 2015. Plos One. 10, e0118627.
          Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
          Li, B., et al. 2010. FEBS Lett. 584,3359.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-November-2016 JSW
          SynonymsCiliary Neurotrophic Factor Epitope Peptide 6
          DescriptionA brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Peptide SequenceAc-VGDGGLFEKKL-NH₂
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml) or H₂O (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKazim, S., et al. 2015. Plos One. 10, e0118627.
          Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
          Li, B., et al. 2010. FEBS Lett. 584,3359.