233105 | CL-82198 - CAS 1188890-36-9 - Calbiochem

233105
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₂N₂O₃ · HCl 1188890-36-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233105-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA selective inhibitor of MMP-13 (IC50 = 10 µM). Binds to the S1′ pocket of MMP-13 with its morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.
          Catalogue Number233105
          Brand Family Calbiochem®
          References
          ReferencesChen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.
          Product Information
          CAS number1188890-36-9
          ATP CompetitiveN
          FormLight yellow solid
          Hill FormulaC₁₇H₂₂N₂O₃ · HCl
          Chemical formulaC₁₇H₂₂N₂O₃ · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMMP-13
          Primary Target IC<sub>50</sub>10 µM against MMP-13
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          233105

          References

          Reference overview
          Chen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          DescriptionA selective inhibitor of MMP-13 (IC50 = 10 µM) that does not appear to act by chelating Zn2+. Binds within the entire S1' pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.
          FormLight yellow solid
          CAS number1188890-36-9
          Chemical formulaC₁₇H₂₂N₂O₃ · HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityH₂O (25 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesChen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.