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23-050 | CHIP Protein, active, 10 µg

23-050
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesCascade Component
      EA Human E3
      Description
      Catalogue Number23-050
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCHIP Protein, active, 10 µg
      Alternate Names
      • Carboxy terminus of Hsp70-interacting protein
      • CLL-associated antigen KW-8
      • Antigen NY-CO-7
      • STIP1 homology and U box-containing protein 1
      • STUB1
      Background InformationCHIP is an E3 ubiquitin-protein ligase which targets misfolded chaperone substrates for proteasomal degradation. It contains multiple domains, including a tetratricopeptide repeat (TPR) domain that allows interaction with molecular chaperones, such as Hsp70 and Hsp90 and a U-box domain that confers its E3 ubiquitin ligase function. It has been demonstrated that CHIP preferentially ubiquitinates chaperone-bound substrates, of which there are a diverse range including CFTR, ErbB2 and LRRK2, but also targets Hsp70 itself to the proteasome for degradation when misfolded substrates are not present. This sequential degradation of misfolded substrate and chaperone provides a homeostatic mechanism for regulating chaperone levels to reflect the status of protein folding within the cytoplasm.
      References
      Product Information
      Applications
      ApplicationActive, full length, recombinant human CHIP. N-terminal 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
      Key Applications
      • Enzyme Assay
      Biological Information
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      23-050M CHIP Protein, active, 250 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases
      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases