505895 CGP 35348 - CAS 123690-79-9 - Calbiochem

505895
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₂₀NO₄P 123690-79-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05895.0001
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          Glass bottle 10 mg
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          Description
          OverviewA selective antagonist of post-synaptic GABAB receptors (IC50 = 34 µM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
          Catalogue Number505895
          Brand Family Calbiochem®
          SynonymsGABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348
          References
          ReferencesRomei, C., et al., 2010. Pharmacol. Res. 61, 547.
          Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
          Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.
          Product Information
          CAS number123690-79-9
          FormWhite solid
          Hill FormulaC₈H₂₀NO₄P
          Chemical formulaC₈H₂₀NO₄P
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGABAB
          Primary Target IC<sub>50</sub>34 µ
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Romei, C., et al., 2010. Pharmacol. Res. 61, 547.
          Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
          Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2013 JSW
          SynonymsGABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348
          DescriptionA selective antagonist of post-synaptic GABAB receptors (IC50 = 34 mM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
          FormWhite solid
          CAS number123690-79-9
          Chemical formulaC₈H₂₀NO₄P
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (100 mM)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesRomei, C., et al., 2010. Pharmacol. Res. 61, 547.
          Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
          Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.