219671 | CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem

219671
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₅Br₂N₃O₃ 328541-79-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219671-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 219675).
          Catalogue Number219671
          Brand Family Calbiochem®
          SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
          References
          ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
          Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
          Product Information
          CAS number328541-79-3
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₉H₁₅Br₂N₃O₃
          Chemical formulaC₁₉H₁₅Br₂N₃O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCFTR
          Primary Target IC<sub>50</sub>95% inhibition at 50 µM
          Primary Target K<sub>i</sub>4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219671

          References

          Reference overview
          Sonawane, N.D., et al. 2006. FASEB J. 20, 130.
          Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
          DescriptionA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
          FormYellow solid
          CAS number328541-79-3
          Chemical formulaC₁₉H₁₅Br₂N₃O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
          Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.