505308 CDDO-Me - CAS 218600-53-4 - Calbiochem

CDDO-Me - CAS 218600-53-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 713200, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Bardoxolone methyl, BARD, Nrf Activator V

505308
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₄₃NO₄ 218600-53-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05308.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFα, Mip1α and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3 mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170 nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARγ, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition.
          Catalogue Number505308
          Brand Family Calbiochem®
          SynonymsNSC 713200, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Bardoxolone methyl, BARD, Nrf Activator V
          References
          ReferencesLiby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
          Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
          Ryu, K., et al. 2010. BMC Cancer 10, 187.
          Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
          Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
          Zou, W., et al. 2004. Cancer Res. 64, 7570.
          Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
          Konopleva, M., et al. 2002. Blood 99, 326.
          Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.
          Product Information
          CAS number218600-53-4
          FormWhite solid
          Hill FormulaC₃₂H₄₃NO₄
          Chemical formulaC₃₂H₄₃NO₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Liby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
          Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
          Ryu, K., et al. 2010. BMC Cancer 10, 187.
          Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
          Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
          Zou, W., et al. 2004. Cancer Res. 64, 7570.
          Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
          Konopleva, M., et al. 2002. Blood 99, 326.
          Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          SynonymsNSC 713200, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Bardoxolone methyl, BARD, Nrf Activator V
          DescriptionA cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFα, Mip1α and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3 mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170 nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARγ, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number218600-53-4
          Chemical formulaC₃₂H₄₃NO₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLiby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
          Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
          Ryu, K., et al. 2010. BMC Cancer 10, 187.
          Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
          Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
          Zou, W., et al. 2004. Cancer Res. 64, 7570.
          Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
          Konopleva, M., et al. 2002. Blood 99, 326.
          Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.