538763 CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem

538763
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₇N₃O₃S 1700637-55-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.38763.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
          Catalogue Number538763
          Brand Family Calbiochem®
          SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
          References
          ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
          Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
          Product Information
          CAS number1700637-55-3
          FormWhite to light brown to brown solid
          Hill FormulaC₂₂H₂₇N₃O₃S
          Chemical formulaC₂₂H₂₇N₃O₃S
          ReversibleY
          Applications
          Biological Information
          Primary TargetCD38
          Primary Target IC<sub>50</sub>7.3 & 1.9 nM for human & mouse CD38, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          538763

          References

          Reference overview
          Haffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
          Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-July-2019 JSW
          SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
          DescriptionA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
          FormWhite to light brown to brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1700637-55-3
          Chemical formulaC₂₂H₂₇N₃O₃S
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
          Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.