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SCC043 | C28/I2 Human Chondrocyte Cell Line

≥1X10⁶ cells/vial  
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      Explore additional Chondrocyte cell lines:
      C20A4 Human Chondrocyte Cell Line (Catalogue Number SCC041)
      TC28a2 Human Chondrocyte Cell Line (Catalogue Number SCC042)

      Key Specifications Table

      Key Applications
      Catalogue NumberSCC043
      DescriptionC28/I2 Human Chondrocyte Cell Line
      OverviewThe chondrocyte is the only specialized cell type present in articular cartilage. They produce secretions to support and repair the cartilage matrix. Human chondrocytes in mature articular cartilage are post-mitotic and terminally differentiated cells. Studies on human chondrocytes have been hampered by the difficulty in obtaining sufficient numbers of primary human chondrocytes from a single joint and by variabilities among donors due to factors such as age and medical conditions.

      C-28/I2 is a clonal line derived from the nonclonal T/C-28a4 cells which were immortalized via retroviral vector-mediated simian virus SV40 Large T antigen (Tag) expression..

      1. Goldring, M.B, Birkhead, J.R., Suen, L.F., Yamin, R., Mizuno, S., Glowacki, J., Arbiser, J.L, Apperley, J.F. (1994) Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J. Clin. Invest 94(6): 2307-2316.
      2. Claassen, H., Schicht, M., Brandt, J., Reuse, K., Schadlich, R., Goldring, M.B., Guddat, S.S., Thate, A., Paulsen, F. C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express hormone and insulin receptors- Useful cells in study of cartilage metabolism. Ann Anat. 193(1): 23-29.
      3. Goldring, M.B. (2004) Culture of immortalized chondrocytes and their use as models of chondrocyte function. Methods Mol. Med. 100: 37-52.
      Alternate Names
      • C-28/I2
      Product Information
      ApplicationC28/I2 Human Chondrocyte Cell Line is widely used as a model cell line for studying normal and pathological cartilage repair mechanisms related to chondrocyte biology and physiology.
      Key Applications
      • Cell Culture
      Application NotesThis product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@emdmillipore.com.
      Biological Information
      ConcentrationPlease refer to lot specific datasheet.
      Cell Line Type
      • Chondrocyte Cells
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges EMD Millipore to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information

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      SCC042 TC28a2 Human Chondrocyte Cell Line Show Pricing & Availability


      Life Science Research > Cell Culture and Systems > Cell Lines