A part of MilliporeSigma

GF178 | C1 Inhibitor,
Human Recombinant

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      Key Specifications Table

      Protein is expressed in E.coli. Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      Catalogue NumberGF178
      DescriptionC1 Inhibitor,
      Human Recombinant
      Alternate Names
      • C1 Inh
      • C1 esterase inhibitor
      • Serpin G1
      Background InformationC1 Inhibitor is a member of the serpin family of structurally related proteins, and is the primary regulator of the immune complement system. C1 Inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1 inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa.
      Recombinant Human C1 Inhibitor is a highly glycosylated glycoprotein containing 445 amino acid residues (49.4kDa), corresponding to amino acids 56 – 500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex.
      Product Information
      PresentationProduct is presented in 10mM Sodium Phosphate, pH 7.5 and is filtered through a 0.2 micron filter before lyophilization.
      Biological Information
      PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      SourceProtein is expressed in E.coli.
      UniProt Number
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceMeasured by its ability to inhibit recombinant human complement component C1a cleavage of a colorimetric peptide substrate, N Carbobenzyloxy-Lys- ThioBenzyl ester (Z-K-SBzl). The expected IC50 is ≤ 2.6 nM.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
      Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
      Packaging Information
      Material Size200µg
      Transport Information
      Supplemental Information

      Related Products & Applications

      Product Families


      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors