505734 | BzATP Triethylammonium Salt - CAS 112898-15-4 - Calbiochem

505734
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N 112898-15-4

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05734.0001
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          Glass bottle 1 mg
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          Description
          OverviewA prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15 µM vs 50 µM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice.
          Catalogue Number505734
          Brand Family Calbiochem®
          Synonyms2ʹ(3ʹ)-O-(4-Benzoylbenzoyl)adenosine-­5ʹ-triphosphate tri(triethylammonium) salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP
          References
          ReferencesMessemer, N., et al. 2013. Neuropharmacology. 73, 122.
          Michel, A.D., et al. 2001. Br. J. Pharmacol. 132, 1501.
          Erb, L., et al. 1990. J. Biol. Chem. 265, 7424.
          William, N., and Coleman, P.S. 1982. J. Biol. Chem. 257, 2834.
          Product Information
          CAS number112898-15-4
          FormWhite solid
          Hill FormulaC₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N
          Chemical formulaC₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Messemer, N., et al. 2013. Neuropharmacology. 73, 122.
          Michel, A.D., et al. 2001. Br. J. Pharmacol. 132, 1501.
          Erb, L., et al. 1990. J. Biol. Chem. 265, 7424.
          William, N., and Coleman, P.S. 1982. J. Biol. Chem. 257, 2834.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2013 JSW
          Synonyms2ʹ(3ʹ)-O-(4-Benzoylbenzoyl)adenosine-­5ʹ-triphosphate tri(triethylammonium) salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP
          DescriptionA prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15 µM vs 50 µM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice.
          FormWhite solid
          CAS number112898-15-4
          Chemical formulaC₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (100 mM)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMessemer, N., et al. 2013. Neuropharmacology. 73, 122.
          Michel, A.D., et al. 2001. Br. J. Pharmacol. 132, 1501.
          Erb, L., et al. 1990. J. Biol. Chem. 265, 7424.
          William, N., and Coleman, P.S. 1982. J. Biol. Chem. 257, 2834.