203988 | Butyrolactone I - CAS 87414-49-1 - Calbiochem

203988
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₄O₇ 87414-49-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203988-200UG
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          Plastic ampoule 200 μg
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          Description
          OverviewA cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.
          Catalogue Number203988
          Brand Family Calbiochem®
          References
          ReferencesFurukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
          Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
          Kitagawa, M., et al. 1994. Oncogene 9, 2549.
          Kitagawa, M., et al. 1993. Oncogene 8, 2425.
          Product Information
          CAS number87414-49-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₄H₂₄O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp34cdk1/cyclinB
          Primary Target IC<sub>50</sub>680 nM against Cdk1
          Purity≥99% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203988

          References

          Reference overview
          Furukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
          Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
          Kitagawa, M., et al. 1994. Oncogene 9, 2549.
          Kitagawa, M., et al. 1993. Oncogene 8, 2425.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-July-2007 RFH
          DescriptionA cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number87414-49-1
          Structure formulaStructure formula
          Purity≥99% by TLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesFurukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
          Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
          Kitagawa, M., et al. 1994. Oncogene 9, 2549.
          Kitagawa, M., et al. 1993. Oncogene 8, 2425.