531000 Brk Inhibitor, Cpd 4f - Calbiochem

531000
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₁₃N₃O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31000.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531000
          Brand Family Calbiochem®
          SynonymsPTK6 Inhibitor, Breast Tumor Kinase Inhibitor
          References
          ReferencesMahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.
          Product Information
          FormLight beige powder
          Hill FormulaC₁₇H₁₃N₃O
          Chemical formulaC₁₇H₁₃N₃O
          Applications
          Biological Information
          Primary TargetBrk
          Primary Target IC<sub>50</sub>3.15 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Brk Inhibitor, Cpd 4f - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Mahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.

          Brochure

          Title
          NPI Flyer- Epigenetics and Nuclear Function Feature (EMD)
          New Products - Antibodies, Small Molecule, Inhibitors

          Technical Info

          Title
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-September-2014 JSW
          SynonymsPTK6 Inhibitor, Breast Tumor Kinase Inhibitor
          DescriptionA cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).
          FormLight beige powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₁₃N₃O
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
          Toxicity Standard Handling
          ReferencesMahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.