203732 Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem

203732
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅₀H₇₀O₁₄ 79580-28-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203732-100UG
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      Stocked 
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          Glass bottle 100 μg
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          Description
          OverviewLipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes. Binds at site 5 on the voltage-sensitive Na+ channel.
          Catalogue Number203732
          Brand Family Calbiochem®
          SynonymsBrevetoxin B, GbTx-2
          References
          ReferencesEdwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
          Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
          Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
          Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
          Baden, G. 1989. FASEB J. 3, 1807.
          Baden, D.G., et al. 1988. Toxicon 26, 97.
          Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
          Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
          Nakanishi, K. 1985. Toxicon 23, 473.
          Baden, D.G., et al. 1982. Toxicon 19, 455.
          Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
          Product Information
          CAS number79580-28-2
          ATP CompetitiveN
          FormTan to white solid
          Hill FormulaC₅₀H₇₀O₁₄
          Chemical formulaC₅₀H₇₀O₁₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNeurotoxin that binds to Na+ channels on nerves and muscles.
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXW5886000
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.


          From Catalog:
          Solubitlity- removed acetone, EtOAc
          End use certificateY
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203732

          References

          Reference overview
          Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
          Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
          Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
          Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
          Baden, G. 1989. FASEB J. 3, 1807.
          Baden, D.G., et al. 1988. Toxicon 26, 97.
          Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
          Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
          Nakanishi, K. 1985. Toxicon 23, 473.
          Baden, D.G., et al. 1982. Toxicon 19, 455.
          Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-May-2008 RFH
          SynonymsBrevetoxin B, GbTx-2
          DescriptionLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na+ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.
          FormTan to white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number79580-28-2
          RTECSXW5886000
          Chemical formulaC₅₀H₇₀O₁₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityEthyl acetate, Methanol or H₂O
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.


          From Catalog:
          Solubitlity- removed acetone, EtOAc
          Toxicity Highly Toxic
          ReferencesEdwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
          Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
          Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
          Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
          Baden, G. 1989. FASEB J. 3, 1807.
          Baden, D.G., et al. 1988. Toxicon 26, 97.
          Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
          Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
          Nakanishi, K. 1985. Toxicon 23, 473.
          Baden, D.G., et al. 1982. Toxicon 19, 455.
          Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Openers