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14-675M | BrSK1 Protein, active, 250 µg

250 µg  Also available in 10 μg size (cat#14-675) and in bulk (cat#14-675-K).
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      Replacement Information
      Catalogue Number14-675M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionBrSK1 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human BrSK1 amino acids 2-end
      Product Information
      ApplicationActive, N-terminal 6His-tagged, recombinant, human BrSK1 amino acids 2-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Entrez Gene Number
      Gene Symbol
      • BRSK1
      • SAD1
      • KIAA1811
      • FLJ43009
      Protein TargetBrSK1
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8TDC3 # Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)- induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.
      COFACTOR: Magnesium.
      SIZE: 794 amino acids; 86753 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.
      TISSUE SPECIFICITY: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
      SIMILARITY: SwissProt: Q8TDC3 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. & Contains 1 protein kinase domain. & Contains 1 UBA domain.
      Molecular Weight88.4kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of CHKtide (Catalog # 12-373)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-675) and in bulk (cat#14-675-K).
      Transport Information
      Supplemental Information


      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-675 BrSK1 Protein, active, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases