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14-499 | Bmx Protein, active, 10 µg

14-499
10 µg  Also available in 250μg size as catalog # 14-499M - Call for pricing and availability.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-499
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionBmx Protein, active, 10 µg
      OverviewN-terminal His6 tagged, recombinant, full length, human Bmx
      References
      Product Information
      Applications
      ApplicationActive, N-terminal His6 tagged, recombinant, full length, human Bmx, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryTyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC (MIM 600583), TXK (MIM 600058), ITK (MIM 186973), and BTK (MIM 300300). All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[supplied by OMIM]
      Gene Symbol
      • BMX
      • PSCTK2
      • PSCTK3
      • NTK38
      • ETK
      Protein TargetBmx
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51813 # Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.
      COFACTOR: Binds 1 zinc ion per subunit (By similarity).
      SIZE: 675 amino acids; 78011 Da
      SUBUNIT: Interacts with RUFY1 and RUFY2.
      SUBCELLULAR LOCATION: Cytoplasm (Probable).
      TISSUE SPECIFICITY: Preferentially expressed in epithelial and endothelial cells.
      DOMAIN: SwissProt: P51813 SH2 domain mediates interaction with RUFY1.
      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
      Molecular Weight79kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size as catalog # 14-499M - Call for pricing and availability.
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-499M Bmx Protein, active, 250 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases