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203401 | Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem

203401
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      9041-93-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203401-10MG
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          Glass bottle 10 mg
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          Description
          OverviewMixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
          Catalogue Number203401
          Brand Family Calbiochem®
          References
          ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
          Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
          Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
          Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
          Arkin, H., et al. 1989. Cancer Res. 49, 6556.
          Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
          Takita, T., et al. 1968. Antibiotics 21, 79.
          Product Information
          CAS number9041-93-4
          FormWhite to off-white solid
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Biological activityPotency: 1.5-2.0 U/mg
          Purity≥90% by HPLC (A₂ + B₂)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEC5991990
          Safety Information
          R PhraseR: 20/21/22-36/37/38-40-42/43

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          Limited evidence of a carcinogenic effect.
          May cause sensitization by inhalation and skin contact.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203401

          References

          Reference overview
          Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
          Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
          Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
          Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
          Arkin, H., et al. 1989. Cancer Res. 49, 6556.
          Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
          Takita, T., et al. 1968. Antibiotics 21, 79.

          Brochure

          Title
          Antibiotics Profiler
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2007 JSW
          DescriptionA mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
          FormWhite to off-white solid
          CAS number9041-93-4
          RTECSEC5991990
          Purity≥90% by HPLC (A₂ + B₂)
          Biological activityPotency: 1.5-2.0 U/mg
          SolubilityH₂O (20 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 1318
          ReferencesTounekki, O., et al. 1994. Bull. Cancer 81, 1043.
          Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
          Ikeda, S., et al. 1991. Anal. Biochem. 192, 96.
          Hait, W.N., et al. 1990. Cancer Res. 50, 6636.
          Arkin, H., et al. 1989. Cancer Res. 49, 6556.
          Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694.
          Takita, T., et al. 1968. Antibiotics 21, 79.