197217 | Bcl-xL BH4₄₋₂₃, Human, Cell-Permeable - Calbiochem

197217
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      197217-1MG
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      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable peptide that prevents apoptotic cell death by directly binding to the voltage-dependent anion channel (VDAC) and blocking its activity. Leads to the inhibition of cytochrome c release and loss of mitochondrial membrane potential (ΔΨm). Contains the conserved N-terminal homology domain (BH4) of Bcl-xL (amino acids 4 - 23) that has been shown to be essential for inhibiting VDAC activity in liposomes and in isolated mitochondria. The BH4 domain is linked to a carrier peptide, a 10-amino acid HIV-TAT48-57 sequence with a β-alanine residue as a spacer for maximum flexibility. Following its uptake, it is mainly localized to the mitochondria.
          Catalogue Number197217
          Brand Family Calbiochem®
          SynonymsHIV-TAT₄₈₋₅₇-β-Ala-Bcl-xL BH4₄₋₂₃, Ac-GRKKRRQRRR-βA-SNRELVVDFLSYKLSQKGYS-OH
          References
          ReferencesChen m., et al. 2002. J. Biol. Chem. 277, 29181.
          Futaki, S., et al. 2001. J. Biol. Chem. 276, 5836.
          Shimizu, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 3100.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₆₅H₂₇₉N₅₉O₄₆
          Chemical formulaC₁₆₅H₂₇₉N₅₉O₄₆
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetVoltage-dependent anion channel (VDAC)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-βAla-Ser-Asn-Arg-Glu-Leu-Val-Val-Asp-Phe-Leu-Ser-Tyr-Lys-Ser-Gln-Lys-Gly-Tyr-Ser-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          197217

          References

          Reference overview
          Chen m., et al. 2002. J. Biol. Chem. 277, 29181.
          Futaki, S., et al. 2001. J. Biol. Chem. 276, 5836.
          Shimizu, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 3100.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-July-2007
          SynonymsHIV-TAT₄₈₋₅₇-β-Ala-Bcl-xL BH4₄₋₂₃, Ac-GRKKRRQRRR-βA-SNRELVVDFLSYKLSQKGYS-OH
          DescriptionA highly cell-permeable peptide that prevents apoptotic cell death by directly binding to the voltage-dependent anion channel (VDAC) and blocking its activity. Ultimately results in the inhibition of cytochrome c release and loss of mitochondrial membrane potential (ΔΨm). Contains the conserved N-terminal homology domain (BH4) of Bcl-xL (amino acids 4-23) that has been shown to be essential for inhibiting VDAC activity in liposomes and isolated mitochondria. The BH4 domain is linked to the carrier peptide, the 10-amino acid HIV-TAT48-57 sequence with a β-alanine residue as a spacer for maximum flexibility. Following its uptake, it is mainly localized in the mitochondria.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆₅H₂₇₉N₅₉O₄₆
          Peptide SequenceAc-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-βAla-Ser-Asn-Arg-Glu-Leu-Val-Val-Asp-Phe-Leu-Ser-Tyr-Lys-Ser-Gln-Lys-Gly-Tyr-Ser-OH
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or 20% Acetic Acid (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesChen m., et al. 2002. J. Biol. Chem. 277, 29181.
          Futaki, S., et al. 2001. J. Biol. Chem. 276, 5836.
          Shimizu, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 3100.