196440 Batimastat - CAS 130370-60-4 - Calbiochem

196440
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₃₁N₃O₄S₂ 130370-60-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      196440-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508408).
          Catalogue Number196440
          Brand Family Calbiochem®
          Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
          References
          ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
          Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
          Parvathy, S., et al. 1998. Biochemistry 37, 1680.
          Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
          Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
          Moss, M.L., et al. 1997. Nature 385, 733.
          Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
          Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
          Wang, X., et al. 1994. Cancer Res. 54, 4726.
          Davies, B., et al. 1993. Cancer Res. 53, 2087.
          Product Information
          CAS number130370-60-4
          FormOff-white solid
          Hill FormulaC₂₃H₃₁N₃O₄S₂
          Chemical formulaC₂₃H₃₁N₃O₄S₂
          Structure formula ImageStructure formula Image
          Applications
          ApplicationBatimastat, CAS 130370-60-4, is a potent inhibitor of a several metalloproteinases, including MMP-1, 2, 3, 7, 9, ΔMT1, ADAM8 & ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3 & 19 nM, respectively).
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          196440

          References

          Reference overview
          Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
          Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
          Parvathy, S., et al. 1998. Biochemistry 37, 1680.
          Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
          Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
          Moss, M.L., et al. 1997. Nature 385, 733.
          Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
          Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
          Wang, X., et al. 1994. Cancer Res. 54, 4726.
          Davies, B., et al. 1993. Cancer Res. 53, 2087.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-August-2010 RFH
          Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
          DescriptionA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number130370-60-4
          Chemical formulaC₂₃H₃₁N₃O₄S₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
          Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
          Parvathy, S., et al. 1998. Biochemistry 37, 1680.
          Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
          Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
          Moss, M.L., et al. 1997. Nature 385, 733.
          Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
          Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
          Wang, X., et al. 1994. Cancer Res. 54, 4726.
          Davies, B., et al. 1993. Cancer Res. 53, 2087.