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203325 | BMS - CAS 145626-87-5 - Calbiochem

203325
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₁₀O₂S₃ 145626-87-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203325-1GM
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          Glass bottle 1 gm
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          Description
          OverviewWater-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.
          Catalogue Number203325
          Brand Family Calbiochem®
          Synonymsbis(2-Mercaptoethylsulfone)
          References
          ReferencesSingh, R., et al. 1995. Methods Enzymol. 251, 167.
          Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
          Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
          Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.
          Product Information
          CAS number145626-87-5
          FormWhite crystalline solid
          Hill FormulaC₄H₁₀O₂S₃
          Chemical formulaC₄H₁₀O₂S₃
          PKA7.9 and 9.0
          Structure formula Image
          Applications
          Biological Information
          Purity≥99% by titration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203325

          References

          Reference overview
          Singh, R., et al. 1995. Methods Enzymol. 251, 167.
          Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
          Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
          Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.

          Brochure

          Title
          Cleland's Reagent (Dithiothreitol) Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonymsbis(2-Mercaptoethylsulfone)
          DescriptionWater-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pKa of 7.9 and 9.0.
          FormWhite crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number145626-87-5
          Chemical formulaC₄H₁₀O₂S₃
          Structure formula
          Purity≥99% by titration
          SolubilityDMSO, Ethanol, H₂O (1.8 mg/ml), or Methanol. May require warming (40-45°C) to achieve complete solubilization in H₂O.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesSingh, R., et al. 1995. Methods Enzymol. 251, 167.
          Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem. 22, 109.
          Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
          Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem. 58, 633.