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GF168 | BMP-6 Protein, Human Recombinant

GF168
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SourcePurity
      HEK293 Cells Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      Description
      Catalogue NumberGF168
      DescriptionBMP-6 Protein, Human Recombinant
      Alternate Names
      • Bone Morphogenetic Protein 6
      • BMP6
      • VRR-1
      • VG-1-related protein
      Background InformationBone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
      References
      Product Information
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
      Applications
      ApplicationThe Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily.
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses
      SourceHEK293 Cells
      Cross ReactivityNone
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Recombinant Human BMP-6 - 2382649 2382649
      Recombinant Human -2719439 2719439
      Recombinant Human -2734721 2734721
      Recombinant Human BMP-6 - 2092749 2092749
      Recombinant Human BMP-6 - 2202474 2202474
      Recombinant Human BMP-6 - 2211058 2211058
      Recombinant Human BMP-6 - 2228118 2228118
      Recombinant Human BMP-6 - 2280910 2280910
      Recombinant Human BMP-6 - 2297278 2297278
      Recombinant Human BMP-6 - Q2007174 Q2007174
      Recombinant Human BMP-6 Recombinant Protein - 2192165 2192165

      Brochure

      Title
      New Products: Volume 3, 2012

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors