197900 BEC, Hydrochloride - Calbiochem

197900
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₅H₁₂BNO₄S · HCl

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      197900-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
          Catalogue Number197900
          Brand Family Calbiochem®
          Synonyms(S)-(2-Boronoethyl)-L-cysteine, HCI)
          References
          ReferencesColleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
          Kim, N.N., et al. 2001. Biochemistry 40, 2678.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₅H₁₂BNO₄S · HCl
          Chemical formulaC₅H₁₂BNO₄S · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationBEC, Hydrochloride, CAS 63107-40-4, is a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human type II arginase). Does not inhibit nitric oxide synthase.
          Biological Information
          Primary Targetarginase 1, arginase 2
          Primary Target K<sub>i</sub>310 nM for human recombinant type II arginase, pH 7.5
          Purity≥97% by NMR
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          197900

          References

          Reference overview
          Colleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
          Kim, N.N., et al. 2001. Biochemistry 40, 2678.

          Brochure

          Title
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2010 RFH
          Synonyms(S)-(2-Boronoethyl)-L-cysteine, HCI)
          DescriptionA boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₅H₁₂BNO₄S · HCl
          Structure formulaStructure formula
          Purity≥97% by NMR
          SolubilityH₂O (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
          Toxicity Harmful
          ReferencesColleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356.
          Kim, N.N., et al. 2001. Biochemistry 40, 2678.