Product Information
Applications
ApplicationBAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.
Biological Information
Primary TargetTNF-α-inducible phosphorylation of IκBα
Primary Target IC<sub>50</sub>10 µM inhibiting TNF-α-inducible phosphorylation of IκBα
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

BAY 11-7082 - CAS 19542-67-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BAY 11-7082 - CAS 19542-67-7 - Calbiochem Certificates of Analysis

TitleLot Number
196870

References

Reference overview
Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)

Citations

Title
  • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
  • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
  • Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295.
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision27-September-2010 RFH
    Synonyms(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
    DescriptionPotential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
    FormOff-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number19542-67-7
    Chemical formulaC₁₀H₉NO₂S
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (200 mg/ml)
    Storage +2°C to +8°C
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
    Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
    Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
    Citation
  • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
  • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
  • Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295.
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
  • Related Products & Applications

    Categories

    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cell Adhesion Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation