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GF136 | BAFF Protein, Recombinant human

GF136
20 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT, Cult Human E.coli Greater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1 EU/ug) of BAFF.
      Description
      Catalogue NumberGF136
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionBAFF Protein, Recombinant human
      OverviewHuman BAFF (B-cell activating factor belonging to the TNF family) is a novel ligand in the TNF family. BAFF plays an important role as co-stimulator of B-cell proliferation and function. Recombinant human BAFF is a soluble 17.0 kDa protein containing 153 amino acid residues, comprising the TNF-like extracellular domain of BAFF.
      Alternate Names
      • B-cell Activation Factor
      • TALL-1
      • THANK
      • BLyS
      References
      Product Information
      PresentationLyophilized from sterile filtered 0.5X PBS, pH 7.5, and 0.5 mM DTT, containing no additives.
      Applications
      ApplicationThe Human BAFF protein (B-cell activating factor belonging to the TNF family) is a novel ligand in the TNF family.
      Key Applications
      • Cell Culture
      • Stem Cell Culture
      Biological Information
      PurityGreater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1 EU/ug) of BAFF.
      SourceE.coli
      Specific ActivityHuman BAFF is biologically active when compared to standards. The ED50 as determined by its dose-dependent mitogenic activity on human RPMI 8226 cells is 5-10 ng/mL.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.
      Gene Symbol
      • TNFSF13B
      • BLyS
      • TNFSF20
      • CD257
      • BAFF
      • TALL1
      • DTL
      • TALL-1
      • ZTNF4
      • THANK
      • BLYS
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y275 # Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
      SIZE: 285 amino acids; 31223 Da
      SUBUNIT: Homotrimer.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.
      TISSUE SPECIFICITY: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
      PTM: The soluble form derives from the membrane form by proteolytic processing. & N-glycosylated.
      SIMILARITY: SwissProt: Q9Y275 ## Belongs to the tumor necrosis factor family.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Induced Pluripotent Stem Cells
      Molecular Weight17.0 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C for up to one year from date of receipt. Reconstituted material can be stored at 2°-8°C for one week, but undiluted aliquots at -20°C are recommended. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      BAFF, HUMAN RECOMBINANT PROTEIN - 2031374 2031374
      BAFF, HUMAN RECOMBINANT PROTEIN - DAM1576845 DAM1576845
      BAFF, HUMAN RECOMBINANT PROTEIN - DAM1612128 DAM1612128
      BAFF, HUMAN RECOMBINANT PROTEIN - JBC1889919 JBC1889919
      BAFF, HUMAN RECOMBINANT PROTEIN -2573562 2573562

      Data Sheet

      Title
      BAFF, HUMAN RECOMBINANT PROTEIN

      Newsletters / Publications

      Title
      Cellutions Newsletter: 2007, Volume 1
      Cellutions Newsletter: 2008, Volume 1
      Cellutions Newsletter: 2008, Volume 2
      Cellutions Newsletter: 2008, Volume 3

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors