189485 | Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem

189485
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇₇H₂₉₁N₅₇O₃₉S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189485-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitor that contains the Antennapedia transport peptide sequence fused to the amino terminus of AIP-II (Cat. No. 189484).
          Catalogue Number189485
          Brand Family Calbiochem®
          SynonymsAnt-A3K/V10F-AIP, Ant-AIP-II, Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH
          References
          ReferencesWatterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
          Ishida, A., et al. 1998. FEBS Lett. 427, 115.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₇₇H₂₉₁N₅₇O₃₉S
          Chemical formulaC₁₇₇H₂₉₁N₅₇O₃₉S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          ApplicationAutocamtide-2 Related Inhibitory Peptide II, Cell-permeable, is a specific, potent inhibitor of CaMKII. Contains the Antennapedia transport peptide fused to the amino terminus of AIP-II.
          Biological Information
          Primary Targetcam Kinase-2
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189485

          References

          Reference overview
          Watterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
          Ishida, A., et al. 1998. FEBS Lett. 427, 115.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          SynonymsAnt-A3K/V10F-AIP, Ant-AIP-II, Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH
          DescriptionA highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II) (Cat. No. 189484). AIP-II is an AIP analog where Ala3 and Val10 are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala286) and KN-93 (Cat. No. 422708). Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇₇H₂₉₁N₅₇O₃₉S
          Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml), H₂O (1 mg/ml), or 5% Acetic Acid (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesWatterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
          Ishida, A., et al. 1998. FEBS Lett. 427, 115.