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189406 | Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

189406
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₂F₂N₆O₃S • CH₃CN 443797-96-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189406-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 - 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
          Catalogue Number189406
          Brand Family Calbiochem®
          Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
          References
          ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
          Lin R., et al. 2005. J. Med. Chem. 48, 4208.
          Product Information
          CAS number443797-96-4
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
          Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetAurora Kinase/Cdk
          Primary Target IC<sub>50</sub>11 and 15 nM for Aurora-A, Aurora-B, respectively; 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189406

          References

          Reference overview
          Emanuel, S., et al. 2005. Cancer Res. 65, 9038.
          Lin R., et al. 2005. J. Med. Chem. 48, 4208.

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
          DescriptionA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112-514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number443797-96-4
          Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
          Structure formula
          Purity≥97% by HPLC
          SolubilityDMSO (15 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
          Lin R., et al. 2005. J. Med. Chem. 48, 4208.