189400 Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem

189400
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₁₄O₉ 4431-00-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189400-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewA cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC50 = 22 µM and IC50 = 10 µM for µ-calpain and m-calpain, respectively).
          Dye content: ~85%.
          Catalogue Number189400
          Brand Family Calbiochem®
          SynonymsATA
          References
          ReferencesLozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
          Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
          Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
          Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
          Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
          Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
          Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
          Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.
          Product Information
          CAS number4431-00-9
          ATP CompetitiveN
          FormRed solid
          Hill FormulaC₂₂H₁₄O₉
          Chemical formulaC₂₂H₁₄O₉
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA topoisomerase 2
          Primary Target IC<sub>50</sub>75 nM against DNA topoisomerase II
          Purity≥85% by dye content
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGU4790000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189400

          References

          Reference overview
          Lozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
          Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
          Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
          Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
          Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
          Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
          Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
          Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.

          Brochure

          Title
          MAP Kinases Technical Bulletin
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-September-2007 RFH
          SynonymsATA
          DescriptionA cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is also a potent inhibitor of DNA topoisomerase II. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA has been reported to stimulate the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase C-γ. Dye content: ~85%.
          FormRed solid
          CAS number4431-00-9
          RTECSGU4790000
          Chemical formulaC₂₂H₁₄O₉
          Structure formulaStructure formula
          Purity≥85% by dye content
          Solubility0.1 M NaOH (35 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          ReferencesLozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
          Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
          Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
          Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
          Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
          Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
          Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
          Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.