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182541 | Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

182541
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₁N₅ 112809-51-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      182541-25MG
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      Limited AvailabilityLimited Availability
      Stocked 
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      Available
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          Glass bottle 25 mg
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          Description
          OverviewAn orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
          Catalogue Number182541
          Brand Family Calbiochem®
          Synonyms4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
          References
          ReferencesHou, X., et al. 2011. Cancer Res. 71, 7597.
          Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
          Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
          Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
          Product Information
          CAS number112809-51-5
          FormWhite powder
          Hill FormulaC₁₇H₁₁N₅
          Chemical formulaC₁₇H₁₁N₅
          Structure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          182541

          References

          Reference overview
          Hou, X., et al. 2011. Cancer Res. 71, 7597.
          Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
          Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
          Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2012 JSW
          Synonyms4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
          DescriptionAn orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number112809-51-5
          Chemical formulaC₁₇H₁₁N₅
          Structure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml; clear, colorless solution) or Ethanol (< 5 mg/ml; partially soluble)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesHou, X., et al. 2011. Cancer Res. 71, 7597.
          Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
          Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
          Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.