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14-521M | Arg Protein, active, human, 250 µg

14-521M
250 µg  Also available in 10 μg size (cat#14-521) and in bulk (cat#14-521-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-521M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionArg Protein, active, human, 250 µg
      OverviewN-terminal His6-tagged recombinant human Arg, residues 38-end.
      References
      Product Information
      Applications
      ApplicationActive, human, N-terminal His6-tagged recombinant human Arg, residues 38-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman Arg expressed by baculovirus in Sf21 insect cells.
      Entrez Gene Number
      Entrez Gene SummaryThe gene product is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. This gene is expressed in both normal and tumor cells. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
      Gene Symbol
      • ABL2
      • Abelson-related
      • ABLL
      • ARG
      Protein TargetArg
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42684 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics.
      COFACTOR: Magnesium or manganese.
      SIZE: 1182 amino acids; 128343 Da
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: Widely expressed.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: P42684 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight121.9 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Abltide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-521) and in bulk (cat#14-521-K).
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-521 Arg Protein, active, human, 10 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases