181198 | Arachidonic Acid - CAS 506-32-1 - Calbiochem

181198
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₂O₂ 506-32-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      181198-100MG
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          Glass bottle 100 mg
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          181198-1GM
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              Plastic ampoule 1 gm
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              Description
              OverviewPrecursor for prostaglandins, prostacyclin, and thromboxane. Binds to G-protein α-subunits in a covalent, post-translational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets. Modulates nitric oxide production by prostaglandin synthesis via the cyclooxygenase pathway.
              Catalogue Number181198
              Brand Family Calbiochem®
              Synonymscis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid, 20:4
              References
              ReferencesHallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
              Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
              Han, J.-W., et al. 1991. Science 252, 576.
              Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
              Neddleman P., et al. 1986. Annu. Rev. Biochem. 55, 69.
              Product Information
              CAS number506-32-1
              ATP CompetitiveN
              FormColorless oil
              Hill FormulaC₂₀H₃₂O₂
              Chemical formulaC₂₀H₃₂O₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetRas-GAP
              Purity≥99% by TLC and GC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSCE6675000
              Safety Information
              R PhraseR: 20/21/22-36/37/38

              Harmful by inhalation, in contact with skin and if swallowed.
              Irritating to eyes, respiratory system and skin.
              S PhraseS: 36-26

              Wear suitable protective clothing.
              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Dry Ice Only
              Toxicity Harmful
              Storage ≤ -70°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              181198

              References

              Reference overview
              Hallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
              Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
              Han, J.-W., et al. 1991. Science 252, 576.
              Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
              Neddleman P., et al. 1986. Annu. Rev. Biochem. 55, 69.

              Brochure

              Title
              Nitric Oxide and Oxidative Stress Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision15-April-2008 RFH
              Synonymscis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid, 20:4
              DescriptionA cis-polyunsaturated fatty acid found in the plasma membrane. Major component of membrane phospholipids. Following its release by cellular phospholipases, it is enzymatically converted to a variety of inflammatory and vasoactive metabolites, such as prostaglandins (via the cyclooxygenase pathway), leukotrienes (via the lipoxygenase pathway), and epoxides (via the cytochrome P450 pathway). Binds to G-protein α-subunits in a covalent, posttranslational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets.
              FormColorless oil
              Intert gas (Yes/No) Packaged under inert gas
              CAS number506-32-1
              RTECSCE6675000
              Chemical formulaC₂₀H₃₂O₂
              Structure formulaStructure formula
              Purity≥99% by TLC and GC
              SolubilityEthanol (5 mg/ml)
              Storage ≤ -70°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Harmful
              Merck USA index14, 765
              ReferencesHallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
              Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
              Han, J.-W., et al. 1991. Science 252, 576.
              Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
              Neddleman P., et al. 1986. Annu. Rev. Biochem. 55, 69.