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616370 | Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

616370
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      9087-70-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      616370-100MG
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          Glass bottle 100 mg
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          616370-10MG
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              Glass bottle 10 mg
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              616370-20MG
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                  Glass bottle 20 mg
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                  Description
                  OverviewA competitive and reversible inhibitor of esterases and proteases. Forms a tight complex with and blocks the active site of the enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the prephase of blood clotting, kallikrein (Kd = 1 x 10-7 M), plasmin (Kd = 2.3 x 10-10 M) , tissue and leukocytic proteinases, and trypsin (Kd = 5 x 10-14 M). Does not inhibit Factor Xa and thrombin. It is relatively acid- and heat-stable. Useful as a serine protease inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
                  Effectively inhibits target proteases at equimolar concentration.
                  Note: 1 KIU = 0.025 antiplasmin units (APU) = 0.0016 trypsin inhibitor units (using porcine trypsin) = 0.0009756 trypsin inhibitor units (using bovine trypsin).
                  Catalogue Number616370
                  Brand Family Calbiochem®
                  SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
                  References
                  ReferencesZhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
                  Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
                  Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
                  Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
                  Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
                  McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
                  Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
                  Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
                  Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
                  Product Information
                  CAS number9087-70-1
                  Activity≥5500 KIU/mg dry weight
                  Unit of DefinitionOne Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
                  ATP CompetitiveN
                  FormWhite to off-white crystalline solid
                  Hygroscopic Hygroscopic
                  PI10.5
                  ReversibleY
                  Applications
                  Biological Information
                  Primary Targetchymotrypsin
                  Primary Target IC<sub>50</sub>Kd = 1 x 10-7 M, 2.3 x 10-10 M, 5 x 10-14 M, against kallikrein, plasmin, and trypsin, respectively
                  Purity≥95% by gel filtration
                  Physicochemical Information
                  Cell permeableN
                  Contaminantsendotoxin: ≤10 EU/mg
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSYN5080000
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage +2°C to +8°C
                  Hygroscopic Hygroscopic
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  616370

                  References

                  Reference overview
                  Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
                  Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
                  Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
                  Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
                  Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
                  McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
                  Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
                  Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
                  Kassell, B., et al. 1970. Methods Enzymol. 19, 845.

                  Brochure

                  Title
                  Protease and Phosphatase Inhibitor Cocktails Brochure

                  Citations

                  Title
                • Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision28-February-2012 RFH
                  SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
                  DescriptionA competitive and reversible inhibitor of esterase and protease activity. Forms a tight complex with and blocks the active site of target enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the pre-phase of blood clotting, kallikrein (Kd = 1 X 10-7 M), plasmin (Kd = 2.3 X 10-10 M), tissue and leukocyte proteinases, and trypsin (Kd = 5 X 10-14 M). Does not inhibit Factor Xa or thrombin. Reported to be relatively acid and heat stable. Effectively inhibits target proteases at equimolar concentration. Useful as a serine proteinase inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
                  FormWhite to off-white crystalline solid
                  CAS number9087-70-1
                  RTECSYN5080000
                  Purity≥95% by gel filtration
                  Contaminantsendotoxin: ≤10 EU/mg
                  Activity≥5500 KIU/mg dry weight
                  Unit definitionOne Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
                  SolubilityH₂O (10 mg/ml)
                  Storage +2°C to +8°C
                  Hygroscopic
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
                  Toxicity Standard Handling
                  Merck USA index14, 757
                  ReferencesZhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
                  Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
                  Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
                  Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
                  Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
                  McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
                  Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
                  Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
                  Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
                  Citation
                • Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.