178494 | Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

178494
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀ClF₃N₂O₃ 426834-38-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178494-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
          Catalogue Number178494
          Brand Family Calbiochem®
          SynonymsNS3694
          References
          ReferencesLademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
          Product Information
          CAS number426834-38-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₁₀ClF₃N₂O₃
          Chemical formulaC₁₅H₁₀ClF₃N₂O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetApoptosome complex formation
          Primary Target IC<sub>50</sub>50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          178494

          References

          Reference overview
          Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-June-2009 JSW
          SynonymsNS3694
          DescriptionA cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.
          FormWhite solid
          CAS number426834-38-0
          Chemical formulaC₁₅H₁₀ClF₃N₂O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml). Slightly soluble in ethanol.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.