178278 Apigenin - CAS 520-36-5 - Calbiochem

178278
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀O₅ 520-36-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178278-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewInduces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation.
          Catalogue Number178278
          Brand Family Calbiochem®
          Synonyms4ʹ,5,7-Trihydroxyflavone
          References
          ReferencesKuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
          Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
          Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
          Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.
          Product Information
          CAS number520-36-5
          ATP CompetitiveN
          FormYellow crystalline solid
          Hill FormulaC₁₅H₁₀O₅
          Chemical formulaC₁₅H₁₀O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMAP kinase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLK9276000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 36-26

          Wear suitable protective clothing.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          178278

          References

          Reference overview
          Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
          Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
          Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
          Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.

          Brochure

          Title
          MAP Kinases Technical Bulletin
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-March-2009 RFH
          Synonyms4ʹ,5,7-Trihydroxyflavone
          DescriptionA plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G2/M arrest and to induce morphological differentiation.
          FormYellow crystalline solid
          CAS number520-36-5
          RTECSLK9276000
          Chemical formulaC₁₅H₁₀O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or hot Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.
          Toxicity Irritant
          Merck USA index14, 730
          ReferencesKuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
          Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
          Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
          Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.