178276 | Apicidin, Fusarium sp. - Calbiochem

178276
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₄H₄₉N₅O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178276-1MG
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          Alu drum 1 mg
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          178276-5MG
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              Alu drum 5 mg
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              Description
              OverviewA potent, cell-permeable inhibitor of histone deacetylase (IC50= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50= 50-100 nM) and induces the transcriptional activation of p21 (WAF1). Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2.
              Catalogue Number178276
              Brand Family Calbiochem®
              Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
              References
              ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
              Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
              Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
              Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
              Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.
              Product Information
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₃₄H₄₉N₅O₆
              Chemical formulaC₃₄H₄₉N₅O₆
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetHistone deacetylase
              Primary Target IC<sub>50</sub>700 pM for parasitic histone deactetylase
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 26/27/28

              Very toxic by inhalation, in contact with skin and if swallowed.
              S PhraseS: 22-26-36/37/39-45

              Do not breathe dust.
              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Highly Toxic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              178276

              References

              Reference overview
              Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
              Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
              Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
              Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
              Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

              Technical Info

              Title
              White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision15-April-2008 RFH
              Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
              DescriptionA potent, cell-permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deactetylase) that also exhibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2 in a reversible manner.
              FormOff-white solid
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₃₄H₄₉N₅O₆
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (50 mg/ml) or Ethanol
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Highly Toxic
              ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
              Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
              Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
              Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
              Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.