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178270 | Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem

178270
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇₉H₁₃₁N₃₁O₂₄S₄ 24345-16-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178270-500UG
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          Glass bottle 500 μg
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          Description
          OverviewPolypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.
          Catalogue Number178270
          Brand Family Calbiochem®
          SynonymsCNCKAPETALCARRCQQH-NH₂
          References
          ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
          Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
          Wang, X., et al. 1994. Brain Res. 662, 83.
          Product Information
          CAS number24345-16-2
          ATP CompetitiveN
          FormWhite solid with dark tan cast
          Hill FormulaC₇₉H₁₃₁N₃₁O₂₄S₄
          Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetAHP-type Ca2+-activated K+ channel
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCD6899900
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          178270

          References

          Reference overview
          Mourre, C., et al. 1997. Brain Res. 778, 405.
          Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
          Wang, X., et al. 1994. Brain Res. 662, 83.

          Brochure

          Title
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          SynonymsCNCKAPETALCARRCQQH-NH₂
          DescriptionA polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; however, it does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Known to induce the secretion of prolactin in a dose-dependent manner.
          FormWhite solid with dark tan cast
          CAS number24345-16-2
          RTECSCD6899900
          Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
          Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
          Purity≥98% by HPLC
          Solubility5% Acetic Acid (2 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
          Toxicity Harmful
          Merck USA index14, 725
          ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
          Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
          Wang, X., et al. 1994. Brain Res. 662, 83.