A part of MilliporeSigma

178223 | Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem

178223
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₄₄N₁₀O₆ · 2HCl 37682-72-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178223-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
          Effective concentration: 1-100 µM.
          Catalogue Number178223
          Brand Family Calbiochem®
          References
          ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
          Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
          Umezawa, H. 1976. Methods Enzymol. 55, 678.
          Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
          Product Information
          CAS number37682-72-7
          ATP CompetitiveN
          FormWhite powder
          Hill FormulaC₂₇H₄₄N₁₀O₆ · 2HCl
          Chemical formulaC₂₇H₄₄N₁₀O₆ · 2HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary Targettrypsin-like serine proteases, papain, and some cysteine proteases
          Primary Target IC<sub>50</sub>300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYV9350800
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          178223

          References

          Reference overview
          Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
          Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
          Umezawa, H. 1976. Methods Enzymol. 55, 678.
          Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.

          Citations

          Title
        • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-September-2014 JSW
          DescriptionA reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.
          FormWhite powder
          CAS number37682-72-7
          RTECSYV9350800
          Chemical formulaC₂₇H₄₄N₁₀O₆ · 2HCl
          Purity≥97% by HPLC
          SolubilityH₂O (1 mg/ml) or DMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
          Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
          Umezawa, H. 1976. Methods Enzymol. 55, 678.
          Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
          Citation
        • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.