05-857 Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal

05-857
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, Vrt WB Rb Purified Monoclonal Antibody
      Description
      Catalogue Number05-857
      Replaces16-249
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal
      Alternate Names
      • KAT13A
      References
      Product Information
      FormatPurified
      Applications
      ApplicationThis Anti-phospho-Src family (Tyr416) Antibody, clone 2N8 is validated for use in WB for the detection of phospho-Src family (Tyr416).
      Key Applications
      • Western Blotting
      Biological Information
      Immunogensynthetic peptide containing the sequence ...NE[pY]TA, where pY corresponds to phosphotyrosine at position 416 of c-Src.
      Clone2N8
      HostRabbit
      Specificityphospho-c-Src (Tyr416)
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Vertebrates
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • SRC
      • c-src
      • p60-Src
      • SRC1
      • c-SRC
      • ASV
      • pp60c-src
      Modifications
      • Phosphorylation
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummarySIZE: 536 amino acids; 59835 Da
      SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
      PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
      SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight60kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot of endogenous phospho-c-Src immunoprecipitated from NIH/3T3 RIPA lysates with anti-Src, clone GD11 agarose beads (Cat # 16-186)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal Certificates of Analysis

      TitleLot Number
      Anti-phospho-Src family (Tyr416), clone 2N8 (rabbit monoclonal IgG) - DAM1437264DAM1437264
      Anti-phospho-Src family (Tyr416), clone 2N8 (rabbit monoclonal IgG) - JBC1361968JBC1361968
      Anti-phospho-Src family (Tyr416), clone 2N8 - 06120472920612047292
      Anti-phospho-Src family (Tyr416), clone 2N8 - 2716727167
      Anti-phospho-Src family (Tyr416), clone 2N8 -26068792606879
      Anti-phospho-Src family (Tyr416), clone 2N8 -27091172709117
      Anti-phospho-Src family (Tyr416), clone 2N8 -27578852757885
      Anti-phospho-Src family (Tyr416), clone 2N8 -28239372823937

      References

      Reference overviewPub Med ID
      Structure and regulation of Src family kinases.
      Boggon, Titus J and Eck, Michael J
      Oncogene, 23: 7918-27 (2004)  2004

      Show Abstract
      15489910 15489910
      The interplay between Src family kinases and receptor tyrosine kinases.
      Bromann, Paul A, et al.
      Oncogene, 23: 7957-68 (2004)  2004

      Show Abstract
      15489913 15489913
      Molecular interdiction of Src-family kinase signaling in hematopoietic cells.
      Geahlen, Robert L, et al.
      Oncogene, 23: 8024-32 (2004)  2004

      Show Abstract
      15489920 15489920
      Src protein-tyrosine kinase structure and regulation.
      Roskoski, Robert
      Biochem. Biophys. Res. Commun., 324: 1155-64 (2004)  2004

      Show Abstract
      15504335 15504335

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies