05-886 | Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Purified Monoclonal Antibody
      Catalogue Number05-886
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal
      Background InformationThe STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation.
      Product Information
      • PDGF treated 3T3/NIH cells
      ApplicationAnti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W is a rabbit monoclonal antibody for detection of phospho-STAT5A/B (Tyr694/699) also known as signal transducer & activator of transcription 5A/B & has been tested in WB.
      Key Applications
      • Western Blotting
      Application NotesNOT recommended for immunoprecipitation
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine at residue 694 of human STAT5A or residue 699 of STAT5B.
      Specificityphospho-STAT5A/B (Tyr694/699)
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NotePredicted to cross react with chimpanzee, bovine and rat based on sequence homology
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
      Gene Symbol
      • STAT5A
      • MGF
      • STAT5
      • Phosphorylation
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
      SIZE: 787 amino acids; 89866 Da
      SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).
      PTM: Tyrosine phosphorylated (By similarity).
      DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
      SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
      Molecular WeightMr 95kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from 3T3/NIH cells treated with PDGF
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      Anti-phospho-STAT5A/B (Tyr694/699), clone A11W - 30314 30314


      Reference overviewApplicationPub Med ID
      A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling.
      Caldarelli, A; Müller, JP; Paskowski-Rogacz, M; Herrmann, K; Bauer, R; Koch, S; Heninger, AK; Krastev, D; Ding, L; Kasper, S; Fischer, T; Brodhun, M; Böhmer, FD; Buchholz, F
      Leukemia  27  2301-10  2013

      Show Abstract
      23508117 23508117
      The regulation of Rasd1 expression by glucocorticoids and prolactin controls peripartum maternal insulin secretion.
      Lellis-Santos, C; Sakamoto, LH; Bromati, CR; Nogueira, TC; Leite, AR; Yamanaka, TS; Kinote, A; Anhê, GF; Bordin, S
      Endocrinology  153  3668-78  2012

      Show Abstract
      22700767 22700767
      Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers.
      Ochsner, SA; Strick-Marchand, H; Qiu, Q; Venable, S; Dean, A; Wilde, M; Weiss, MC; Darlington, GJ
      Stem cells (Dayton, Ohio)  25  2476-87  2007

      Show Abstract
      Western Blotting17641245 17641245
      Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1.
      Gollob, J A, et al.
      Blood, 91: 1341-54 (1998)  1998

      Show Abstract
      9454765 9454765

      Technical Info

      JAK/STAT Signaling Research Focus