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07-875 | Anti-phospho-PKCδ (Ser664) Antibody

07-875
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue Number07-875
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-PKCδ (Ser664) Antibody
      Alternate Names
      • PRKCD
      • PKC delta
      • PKCd
      • Protein Kinase C, delta
      References
      Product Information
      FormatAffinity Purified
      Presentation100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
      Applications
      ApplicationDetect phospho-PKCδ (Ser664) using this Anti-phospho-PKCδ (Ser664) Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesImmunoblot Analysis: A 1:1,000 dilution of this lot detected phospho-PKCδ (Ser664) in RIPA lysate of PMA-treated K562 cells.
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human phospho-PKCδ (Ser664).
      HostRabbit
      SpecificityRecognizes phospho-PKCδ (Ser664), weaker with with mouse and rat PKCδ (Ser662) and PKCα (Ser657) and PKCβII (Ser662).
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NotePredicted to cross-react more weakly with mouse based on sequence homology, but have not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
      Gene Symbol
      • PRKCD
      • MGC49908
      • nPKC-delta
      • MAY1
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q05655 # This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function.
      SIZE: 676 amino acids; 77477 Da
      SUBUNIT: Interacts with PDK1 (By similarity). Interacts with RAD9A and CDCP1.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
      DOMAIN: SwissProt: Q05655 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor. & The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.
      PTM: Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity (By similarity).
      SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
      Molecular Weight78 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti- phospho-PKC#948; (Ser664) - 2152449 2152449
      Anti- phospho-PKCd (Ser664) (Affinity purified Rabbit polyclonal IgG) - 2092613 2092613
      Anti- phospho-PKCd (Ser664) (Affinity purified Rabbit polyclonal IgG) - 2205914 2205914
      Anti- phospho-PKCd (Ser664) (Affinity purified Rabbit polyclonal IgG) - 2274234 2274234
      Anti- phospho-PKCd (Ser664) - 2007679 2007679
      Anti- phospho-PKCd (Ser664) - DAM1661016 DAM1661016
      Anti- phospho-PKCδ (Ser664) - 2527047 2527047
      Anti- phospho-PKCδ (Ser664) -2613735 2613735
      Anti- phospho-PKCδ (Ser664) -2668072 2668072
      Anti- phospho-PKCδ (Ser664) -2764914 2764914
      Anti- phospho-PKC (Ser664) -2805404 2805404
      anti-phospho-PKCdelta; (Ser664) - 0604027264 0604027264
      anti-phospho-PKCdelta; (Ser664) - JBC1386232 JBC1386232

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies