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ABS431 | Anti-phospho-P70S6K (Thr470) Antibody

ABS431
200 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABS431
      DescriptionAnti-phospho-P70S6K (Thr470) Antibody
      Alternate Names
      • Ribosomal protein S6 kinase beta-1
      • S6K-beta-1
      • S6K1
      • 70 kDa ribosomal protein S6 kinase 1
      • P70S6K1
      • p70-S6K 1
      • Ribosomal protein S6 kinase I
      • Serine/threonine-protein kinase 14A
      • p70 ribosomal S6 kinase alpha
      • p70 S6 kinase alpha
      • p70 S6K-alpha
      • p70 S6KA
      Background Information70 kDa ribosomal protein S6 kinase 1 (P70S6K1 or P70S6k) is also known as Ribosomal protein S6 kinase beta-1 (S6K-beta-1 or S6K1), Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, and p70 ribosomal S6 kinase alpha (p70 S6K-alpha or p70 S6KA). P70S6k is a serine/threonine-protein kinase that is part of the downstream mTOR signaling pathway. P70S6k promotes cell proliferation, cell growth, and cell cycle progression in response to growth factors and nutrients, and shows wide tissue expression. P70S6k is activated by mTORC1 and by PDPK1.
      References
      Product Information
      FormatAffinity Purified
      Control
      • MCF7 cell lysate and Rapamycin treated MCF7 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-phospho-P70S6K (Thr470) Antibody is a highly specific rabbit polyclonal antibody, that targets S6 Kinase & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the auto inhibitory domain of human P70S6K phosphorylated at Thr470.
      EpitopeAuto inhibitory domain
      HostRabbit
      SpecificityThis antibody recognizes the auto inhibitory domain of P70S6K phosphorylated at Thr470.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Rat, Mouse, and Chicken based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RPS6KB1
      • STK14A
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~60 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~56 kDa and ~59 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF7 cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected P70S6K phosphorylated at Thr470 in 10 µg of MCF7 cell lysate and Rapamycin treated MCF7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies