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MABS71 | Anti-phospho-MAPK 1/2 (Thr203/Ty205) Antibody, clone 14B9.1

MABS71
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABS71
      Replaces05-481
      DescriptionAnti-phospho-MAPK 1/2 (Thr203/Ty205) Antibody, clone 14B9.1
      Alternate Names
      • Mitogen-activated protein kinase 3
      • MAP kinase 3
      • MAPK 3
      • ERT2
      • Extracellular signal-regulated kinase 1
      • ERK-1
      • Insulin-stimulated MAP2 kinase
      • MAP kinase isoform p44
      • p44-MAPK
      • Microtubule-associated protein 2 kinase
      • p44-ERK1
      Background InformationThe extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called p44 and p42 MAP kinases, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. The 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade. For this reason, the two proteins are often referred to collectively as ERK1/2 or p44/p42 MAP kinase. The ERK1/2 signaling cascade has been shown to be a critical regulator of cell differentiation, cell physiology and neuronal function. Aberrant control of ERK1/2 activity has been implicated in a variety of pathological conditions, including cancer and autoimmune diseases, and efficient study methods are in demand. Extracellular signal/mitogen activated protein kinases (erk/MAPK) are a group of proline-directed serine/threonine kinases that are activated by dual phosphorylation of conserved threonine and tyrosine residues within a characteristic T X Y peptide motif. The mitogen-activated kinases erk1 (MAPK1) and erk2 (MAPK2) acquire full enzymatic activity upon phosphorylation of both threonine and tyrosine residues within the sequence motif T E Y.
      References
      Product Information
      FormatPurified
      Control
      • A431cell lysate and EGF treated A431 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-phospho-MAPK 1/2 (Thr203/Ty205) Antibody, clone 14B9.1 is a highly specific mouse monoclonal antibody & that targets MAPK/Erk1/2 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human MAPK 1/2 phosphorylated at Thr203 and Ty205.
      Clone14B9.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityAntibody recognizes dual phosphorylation of MAPK1/2 at Thr203/Tyr204, but this antibody has not been used for the detection of single phosphorylation at either site.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MAPK3
      • ERK1
      • PRKM3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 44 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A431 cell lysate.

      Western Blotting Analysis: 0.1 µg/mL of this antibody detected phospho-MAPK 1/2 (Thr203/Ty205) in 200 µg of A431cell lysate and EGF treated A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Related Products

      Catalog Number Description  
      05-481 Anti-phospho-MAP Kinase1/2 Antibody Show Pricing & Availability

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies