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09-495 | Anti-phospho LKB1 (Ser431) Antibody

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, R, B, Eq WB Rb Affinity Purified Polyclonal Antibody
      Catalogue Number09-495
      DescriptionAnti-phospho LKB1 (Ser431) Antibody
      Alternate Names
      • Renal carcinoma antigen NY-REN-19
      • Serine/threonine-protein kinase LKB1
      • polarization-related protein LKB1
      • serine/threonine kinase 11
      • erine/threonine kinase 11 (Peutz-Jeghers syndrome)
      • serine/threonine protein kinase 11
      Background InformationLKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome.
      Product Information
      FormatAffinity Purified
      • NIH/3T3 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      ApplicationThis Anti-phospho LKB1 (Ser431) Antibody is validated for use in WB for the detection of phospho LKB1 (Ser431).
      Key Applications
      • Western Blotting
      Application NotesWestern Blot (Snap i.d.®) Analysis: 0.5 µg/mL from a previous lot detected LKB1 on 10 µg of NIH/3T3 treated with forskolin lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human LKB1 when phosphorylated at Ser431.
      EpitopePhosphorylated Ser431
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes LKB1 when phosphorylated at Ser431.
      Species Reactivity
      • Mouse
      • Human
      • Rat
      • Bovine
      • Horse
      Species Reactivity NoteDemonstrated to react with mouse. Predicted to react with human, rat, bovine, and equine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • STK11
      • LKB1
      • PJS
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases By similarity. Tumor suppressor.

      CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. UniProtKB Q15831

      COFACTOR: Magnesium or Manganese (By similarity). UniProtKB Q15831

      ENZYME REGULATION: Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2 By similarity. UniProtKB Q15831

      SUBUNIT STRUCTURE: Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4, STK11IP and WDR6 (By similarity).

      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.

      DEVELOPMENTAL STAGE: Ubiquitously expressed 7-11 dpc. Present in nucleated embryonic blood cells from 9 dpc. Restricted to gastrointestinal tract, testis and lung from days 15-19 dpc.

      DISRUPTION: phenotype Mice die in utero 8.5 to 9.5 dpc due to developmental retardation. Heterozygous mice develop multiple gastric adenomatous polyps.

      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

      Contains 1 protein kinase domain.
      Molecular Weight~ 55 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysate.

      Western Blot Analysis: 0.1 µg/mL of this antibody detected LKB1 on 10 µg of NIH/3T3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies