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07-821 | Anti-phospho-EGFR (Tyr992) Antibody

07-821
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue Number07-821
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-EGFR (Tyr992) Antibody
      Alternate Names
      • epidermal growth factor receptor
      • ERBB
      • ERBB1
      • mENA
      References
      Product Information
      FormatAffinity Purified
      Presentation100 µL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
      Applications
      ApplicationAnti-phospho-EGFR (Tyr992) Antibody detects level of phospho-EGFR (Tyr992) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-EGFR (Tyr992).
      HostRabbit
      SpecificityRecognizes phospho-EGFR (Tyr992)
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NotePredicted to cross-react with mouse and rat based on sequence homology, but have not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • EGFR
      • ERBB1
      • ERBB
      • mENA
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
      SIZE: 1210 amino acids; 134277 Da
      SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
      TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
      PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
      SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
      MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
      Molecular Weight185 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-EGFR (Tyr992) (Affinity purified Rabbit polyclonal IgG) - 2280177 2280177
      Anti-phospho-EGFR (Tyr992) - DAM1412896 DAM1412896
      Anti-phospho-EGFR (Tyr992) - DAM1734738 DAM1734738
      anti-phospho-EGFR (Tyr992) - 0608039223 0608039223
      anti-phospho-EGFR (Tyr992) - 0611045316 0611045316

      References

      Reference overviewPub Med ID
      Identification of an exon 4-deletion variant of epidermal growth factor receptor with increased metastasis-promoting capacity.
      Wang, H; Zhou, M; Shi, B; Zhang, Q; Jiang, H; Sun, Y; Liu, J; Zhou, K; Yao, M; Gu, J; Yang, S; Mao, Y; Li, Z
      Neoplasia (New York, N.Y.) 13 461-71 2011

      Show Abstract Full Text Article
      21532887 21532887
      Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers.
      Kruewel, T; Schenone, S; Radi, M; Maga, G; Rohrbeck, A; Botta, M; Borlak, J
      PloS one 5 e14143 2010

      Show Abstract
      21152443 21152443

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies