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07-788 | Anti-phospho-Abl (Tyr412) Antibody

07-788
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R ELISA, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue Number07-788
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-Abl (Tyr412) Antibody
      Alternate Names
      • ABL1
      • JTK7
      • c-ABL, p150
      • v-abl
      • v-abl Abelson murine leukemia viral oncogene homolog 1
      References
      Product Information
      FormatAffinity Purified
      Applications
      ApplicationThis Anti-phospho-Abl (Tyr412) Antibody is validated for use in ELISA, WB for the detection of phospho-Abl (Tyr412).
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr412.
      HostRabbit
      SpecificityRecognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr412 in Abl.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteOther species have not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
      Gene Symbol
      • ABL1
      • JTK7
      • p150
      • bcr/abl
      • v-abl
      • c-ABL
      • ABL
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
      COFACTOR: Magnesium or manganese.
      SIZE: 1130 amino acids; 122873 Da
      SUBUNIT: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
      TISSUE SPECIFICITY: Widely expressed.
      PTM: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.
      DISEASE: SwissProt: P00519 # A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
      SIMILARITY: SwissProt: P00519 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight145 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-Abl (Tyr412) (Affinity purified Rabbit polyclonal IgG) - 2383447 2383447
      Anti-phospho-Abl (Tyr412) (Affinity purified Rabbit polyclonal IgG) - 2446691 2446691
      Anti-phospho-Abl (Tyr412) (Affinity purified Rabbit polyclonal IgG) - 2028679 2028679
      Anti-phospho-Abl (Tyr412) (Affinity purified Rabbit polyclonal IgG) - 2276286 2276286
      Anti-phospho-Abl (Tyr412) (Affinity purified Rabbit polyclonal IgG)_2837214 2837214
      Anti-phospho-Abl (Tyr412) - DAM1548613 DAM1548613
      Anti-phospho-Abl (Tyr412) - DAM1601812 DAM1601812
      Anti-phospho-Abl (Tyr412) - JBC1913134 JBC1913134
      Anti-phospho-Abl (Tyr412) -2571234 2571234
      Anti-phospho-Abl (Tyr412) -2705100 2705100
      anti-phospho-Abl (Tyr412) - 0603026239 0603026239

      References

      Reference overviewPub Med ID
      c-Abl activates janus kinase 2 in normal hematopoietic cells.
      Tao, W; Leng, X; Chakraborty, SN; Ma, H; Arlinghaus, RB
      The Journal of biological chemistry 289 21463-72 2014

      Show Abstract
      24923444 24923444
      Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
      Walters, Denise K, et al
      Leuk Res, 30:1097-104 (2006) 2006

      16464493 16464493
      Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
      Rush, John, et al
      Nat Biotechnol, 23:94-101 (2005) 2005

      15592455 15592455
      Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
      Salomon, Arthur R, et al.
      Proc. Natl. Acad. Sci. U.S.A., 100: 443-8 (2003) 2003

      Show Abstract
      12522270 12522270
      Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning
      Steen, Hanno, et al
      Mol Cell Proteomics, 2:138-45 (2003) 2003

      12644574 12644574

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies