A part of MilliporeSigma

MAB390-100UG | Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IL M Saporin Monoclonal Antibody
      Catalogue NumberMAB390-100UG
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-p75 LNGFR Antibody, Saporin conjugated, clone 192
      Alternate Names
      • p75 Low Affinity Neurotrophin Receptor
      • NGFR
      Product Information
      PresentationSaporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco's PBS with no preservative.
      ApplicationAnti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 is an antibody against p75 Low Affinity Nerve Growth Factor Receptor for use in 0.
      Key Applications
      • Immunolesioning
      Application NotesImmunotoxin (see "Protocols" for Technical Notes)
      Biological Information
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRat NGF receptor. MAB365 is the monoclonal antibody used for MAB390-SAP
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
      Gene Symbol
      • NGFR
      • p75(NTR)
      • TNFRSF16
      • Gp80-LNGFR
      • CD271
      Non-Reactive Species
      • Human
      • Mouse
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
      SIZE: 427 amino acids; 45183 Da
      SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
      PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
      SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsCentrifuge material at low speed in microfuge to ensure all of the solution is at the bottom of the tube. Vortex gently. Long term storage at -70ºC or below. Short term storage at -20ºC or 2-8ºC with appropriate antibacterial agent if compatible with the intended application. The sterile conjugate is stable at 2-8ºC for several months. Avoid repeated freezing and thawing. Glycerol (1:1) can be added for additional stability if compatible with the intended application. This immunotoxin may be handled safely using standard laboratory procedures as the cross-species reactivity between these anti-rat p75 antibodies and the human form of p75 is negligible.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      192-IgG-SAP IMMUNOTOXIN - 2373403 2373403
      192-IgG-SAP IMMUNOTOXIN - 2437311 2437311
      192-IgG-SAP IMMUNOTOXIN - 2439669 2439669
      192-IgG-SAP IMMUNOTOXIN - 2441969 2441969
      192-IgG-SAP IMMUNOTOXIN - 2003016 2003016
      192-IgG-SAP IMMUNOTOXIN - 2106909 2106909
      192-IgG-SAP IMMUNOTOXIN - 2172725 2172725
      192-IgG-SAP IMMUNOTOXIN - 2192067 2192067
      192-IgG-SAP IMMUNOTOXIN - 2201466 2201466
      192-IgG-SAP IMMUNOTOXIN - 2271186 2271186
      192-IgG-SAP IMMUNOTOXIN - 2324628 2324628
      192-IgG-SAP IMMUNOTOXIN - 2477844 2477844
      192-IgG-SAP IMMUNOTOXIN -2580688 2580688

      References | 18 Available | See All References

      Reference overviewPub Med ID
      Toxin-induced death of neurotrophin-sensitive neurons.
      Wiley, R G
      Methods Mol. Biol., 169: 217-22 (2001) 2001

      11142013 11142013
      Cholinergic depletion reduces plasticity of barrel field cortex.
      Zhu, X O and Waite, P M
      Cereb. Cortex, 8: 63-72 (1998) 1998

      Show Abstract
      9510386 9510386
      Coadministration of galanin antagonist M40 with a muscarinic M1 agonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions.
      McDonald, M P, et al.
      J. Neurosci., 18: 5078-85 (1998) 1998

      Show Abstract
      9634573 9634573
      Removal of cholinergic input to rat posterior parietal cortex disrupts incremental processing of conditioned stimuli.
      Bucci, D J, et al.
      J. Neurosci., 18: 8038-46 (1998) 1998

      Show Abstract
      9742170 9742170
      Hippocampal N-methyl-D-aspartate and kainate binding in response to entorhinal cortex aspiration or 192 IgG-saporin lesions of the basal forebrain.
      Nicolle, M M, et al.
      Neuroscience, 77: 649-59 (1997) 1997

      Show Abstract
      9070742 9070742
      Expression of amyloid precursor protein mRNA isoforms in rat brain is differentially regulated during postnatal maturation and by cholinergic activity.
      Apelt, J, et al.
      Int. J. Dev. Neurosci., 15: 95-112 (1997) 1997

      Show Abstract
      9099621 9099621
      Comparison of site specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin.
      Dornan, W A, et al.
      Behav. Brain Res., 86: 181-9 (1997) 1997

      9134153 9134153
      Selective immunolesions of hippocampal cholinergic input fail to impair spatial working memory.
      McMahan, R W, et al.
      Hippocampus, 7: 130-6 (1997) 1997

      Show Abstract
      9136045 9136045
      Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing.
      Chiba, A A, et al.
      J. Neurosci., 15: 7315-22 (1995) 1995

      Show Abstract
      7472485 7472485
      Ageing: the cholinergic hypothesis of cognitive decline.
      Gallagher, M and Colombo, P J
      Curr. Opin. Neurobiol., 5: 161-8 (1995) 1995

      Show Abstract
      7620303 7620303

      Data Sheet

      Anti-p75 Low Affinity Nerve Growth Factor Receptor, -SAP (Saporin Conjugated), clone 192 - Data Sheet

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