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07-617 | Anti-mGluR1 Antibody

200 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Purified Polyclonal Antibody
      Catalogue Number07-617
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-mGluR1 Antibody
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
      ApplicationAnti-mGluR1 Antibody detects level of mGluR1 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 1180-1199 (C-PNVTYASVILRDYKQSSSTL) of rat mGluR1
      Species Reactivity
      • Rat
      Species Reactivity Notepredicted to cross-react with human and mouse based on sequence homology
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.
      Gene Symbol
      • GRM1
      • MGLUR1A
      • mGlu1
      • GPRC1A
      • mGluR1
      • GRM1A
      • MGLUR1
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13255 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
      SIZE: 1194 amino acids; 132367 Da
      SUBUNIT: Homodimer; disulfide-linked. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: Q13255 ## Belongs to the G-protein coupled receptor 3 family.
      Molecular Weight142kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on mGluR1 in rat brain microsomal preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-mGluR1 (rabbit polyclonal IgG) - 1993946 1993946
      Anti-mGluR1 (rabbit polyclonal IgG) - 2207272 2207272
      Anti-mGluR1 (rabbit polyclonal IgG) - 2343129 2343129
      Anti-mGluR1 - 2040101 2040101
      Anti-mGluR1 - 2494064 2494064
      Anti-mGluR1 - 27060 27060
      Anti-mGluR1 - 32195 32195
      Anti-mGluR1 - DAM1632085 DAM1632085
      Anti-mGluR1 - JBC1813206 JBC1813206
      Anti-mGluR1 - JBC1881347 JBC1881347
      Anti-mGluR1 -2709122 2709122


      Reference overviewApplicationPub Med ID
      MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus.
      Qiu, S; Lu, Z; Levitt, P
      The Journal of neuroscience : the official journal of the Society for Neuroscience 34 16166-79 2014

      Show Abstract
      Immunohistochemistry25471559 25471559
      Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study.
      Deschwanden, A; Karolewicz, B; Feyissa, AM; Treyer, V; Ametamey, SM; Johayem, A; Burger, C; Auberson, YP; Sovago, J; Stockmeier, CA; Buck, A; Hasler, G
      The American journal of psychiatry 168 727-34 2011

      Show Abstract
      21498461 21498461
      Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus.
      Iyo, AH; Feyissa, AM; Chandran, A; Austin, MC; Regunathan, S; Karolewicz, B
      Neuroscience 169 1567-74 2010

      Show Abstract Full Text Article
      Western Blotting20600666 20600666
      Structure and function of glutamate receptor ion channels.
      Mayer, Mark L and Armstrong, Neali
      Annu. Rev. Physiol., 66: 161-81 (2004) 2004

      Show Abstract
      14977400 14977400
      Glutamate and the glutamate receptor system: a target for drug action.
      Bleich, Stefan, et al.
      International journal of geriatric psychiatry, 18: S33-40 (2003) 2003

      12973748 12973748
      Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.
      Ango, F, et al.
      Nature, 411: 962-5 (2001) 2001

      11418862 11418862
      G protein-coupled receptor kinase-mediated desensitization of metabotropic glutamate receptor 1A protects against cell death.
      Dale, L B, et al.
      J. Biol. Chem., 275: 38213-20 (2000) 2000

      Show Abstract
      10982802 10982802
      The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1.
      Sallese, M, et al.
      FASEB J., 14: 2569-80 (2000) 2000

      Show Abstract
      11099476 11099476
      Immunocytochemical localization of the mGluR1 alpha metabotropic glutamate receptor in the dorsal cochlear nucleus.
      Wright, D D, et al.
      J. Comp. Neurol., 364: 729-45 (1996) 1996

      Show Abstract
      8821458 8821458


      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

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      Life Science Research > Antibodies and Assays > Primary Antibodies