A part of MilliporeSigma

MABN1026 | Anti-cAMP Antibody, clone EP8471, rabbit monoclonal

MABN1026
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      A ELISA Rb Unpurified Monoclonal Antibody
      Description
      Catalogue NumberMABN1026
      DescriptionAnti-cAMP Antibody, clone EP8471, rabbit monoclonal
      Alternate Names
      • Cyclic adenosine-3’,5’-monophosphate
      • cAMP
      Background InformationCyclic adenosine monophosphate (cAMP) is an extremely important conveyor of signal transduction. A true, secondary messenger, it plays critical linking roles in a huge array of biological processes, termed the cAMP dependent signaling pathways. cAMP is derived from adenosine triphosphate (ATP) via an adenyl cyclase located on the inner side of the plasma membrane. Adenyl cyclase is activated via numerous stimulatory and inhibitory G protein coupled pathways and partners. cAMP and its associated kinases function in several biochemical processes, including the regulation of glycogen, sugar, and lipid metabolism. cAMP chief kinase is protein kinase A (PKA) or cAMP-dependent protein kinase) PKA is normally inactive as a tetrameric holoenzyme consisting of a regulatory subunit in complex with a catalytic subunit. Binding of cAMP to the regulatory subunits of PKA, releases the catalytic subunits to go free and phosphorylate target proteins. Now cAMP function is not just limited to kinases. cAMP plays a role in modulating intercellular calcium via its direct activation of calcium channels and thereby contributing to the regulation of important hormones like growth hormone. cAMP is also a chemical messenger between cells. cAMP appears to regulate various ion channels called hyperpolarization-activate cyclic nucleotide-gated channels (HCN). When cAMP stimulates the HCN, the channels open, closing the brain cell to communication and thus interfering with the function of the prefrontal cortex. Research into cAMP in terms of brain function is particularly important in age-related illnesses and disorders such as attention deficit hyperactivity disorder (ADHD) of both children and adults. EMD-Millipore’s Anti-cAMP rabbit monoclonal antibody has been tested in both competitive and competitive inhibition ELISA in vitro assays.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect cAMP using this rabbit monoclonal antibody, Anti-cAMP Antibody & clone EP8471 validated for use in ELISA.
      Key Applications
      • ELISA
      Application NotesELISA: A representative lot detected cAMP in ELISA (Competitive Inhibition).
      Biological Information
      ImmunogenKLH conjugated cAMP was used as an immunogen.
      CloneEP8471
      HostRabbit
      SpecificityThis antibody does not cross react with cGMP, GMP, GDP, cIMP, cCMP, and adenosine.
      Species Reactivity
      • All
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • cAMP
      Purification MethodUnpurified
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by ELISA (Competitive Inhibition).

      ELISA: A representative lot detected cAMP in ELISA (Competitive Inhibition).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications