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AB3898 | Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear

AB3898
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB3898
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear
      Alternate Names
      • p150
      • Abl
      • JTK7
      References
      Product Information
      FormatPurified
      PresentationProtein A purified immunoglobulin. Liquid in 0.02 M phosphate buffer with 0.15 M NaCl, pH 7.6 and 0.1% sodium azide as a preservative.
      Applications
      ApplicationDetect c-abl Tyrosine Kinase using this Anti-c-abl Tyrosine Kinase Antibody, cytoplasmic & nuclear validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1,000 (1.0μg/mL).

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant human GST-Abl fusion protein.
      Epitopecytoplasmic & nuclear
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes human Abl. The c-Abl protein is a widely expressed non-receptor tyrosine kinase that is involved in processes of cell differentiation, cell division, cell adhesion, and stress response. This antibody detects an ~120 kDa band, corresponding to the expected molecular weight of human Abl.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
      Gene Symbol
      • ABL1
      • JTK7
      • p150
      • bcr/abl
      • v-abl
      • c-ABL
      • ABL
      • EC 2.7.10.2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
      COFACTOR: Magnesium or manganese.
      SIZE: 1130 amino acids; 122873 Da
      SUBUNIT: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
      TISSUE SPECIFICITY: Widely expressed.
      PTM: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.
      DISEASE: SwissProt: P00519 # A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
      SIMILARITY: SwissProt: P00519 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies